Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease .. Purwanto I. Purpura trombositopenia idiopatik. In: Sudoyo AW. Idiopathic thrombocytopenic purpura (ITP) or immune thrombocytopenic purpura is a disease Purwanto I. Purpura trombositopenia idiopatik.
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IDIOPATIK TROMBOSITOPENIA PURPURA PDF
Hypersensitivity and autoimmune diseases Current guidelines recommend treatment only in cases of significant bleeding. ITP occurs when certain immune system cells produce antibodies against platelets. Am Soc Hematol ;— ITP is an autoimmune disease with antibodies detectable against several platelet surface antigens. ABC of clinical haematology.
Immune thrombocytopenia [1] ITP is a type of thrombocytopenic purpura defined as isolated low platelet count thrombocytopenia with normal bone marrow and the absence of other causes of thrombocytopenia.
Idiopathic thrombocytopenic purpura ITP. To date, the diagnosis of ITP is still arrived at by exclusion, i.
Jayachandranand Khushboo Singh. Spontaneous remissions are unusual in adults. The incidence of ITP is new cases per million per year, with trombositolenia accounting for half of that amount and the median age of adults at the diagnosis is Rarely, splenectomy may be required to manage acute hemorrhage [ 19 ].
It causes a characteristic purpuric rash and an increased tendency to bleed. The coating of platelets with IgG renders them susceptible to opsonization and iiopatik by splenic macrophagesas well by Kupffer cells in the liver. In acute ITP, the stimulus for autoantibody production is also unknown; platelet purpuea cryptantigens may become exposed by the stress of infection, or pseudoantigens may be formed by the passive adsorption of pathogens on platelet surfaces.
Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged. All medications for ITP are given either orally or IV; intramuscular injection is avoided due to the possibility of causing bleeding into the skin. Red Blanchable Erythema Generalized drug eruptions viral exanthems toxic erythema systemic lupus erythematosus.
Durable remission following splenectomy is achieved in 75 percent of ITP cases. Immunodominant epitopes on glycoprotein IIb-IIIa adqlah by autoreactive T cells in patients with immune thrombocytopenic purpura.
Idiopathic thrombocytopenic purpura
Corticosteroids, typically prednisone, are the backbone of the initial treatment. Dapsone for chronic autoimmune thrombocytopenic purpura: Past medical history revealed that patient was known case of epilepsy since 7 years of age and was on tablet eptoin, tablet carbamazepine for past 12 years.
Thrombopoietin receptor agonists are pharmaceutical agents that stimulate platelet production in the bone marrow. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura. General care includes explaining ITP to the patient and advising him or her to watch for bruising, petechiae, trombosiropenia other signs of recurrence.
Journal Statistics View My Stats. The following resources can provide more information on ITP: First, one pur;ura to make sure that there are no other blood abnormalities except for low platelet count and no physical signs except for signs of bleeding. Hematol Oncol Clin Nortn Am ; Open in a separate window. Many older recommendations suggested a certain platelet count threshold usually somewhere below Retrieved from ” https: However, since the diagnosis depends on the exclusion of other causes of a low platelet count, additional investigations such as a bone marrow biopsy may be necessary in some cases.
Pediatric Blood and Cancer.
It is more common in children than adults. Patients are also advised to avoid using aspirin or ibuprofen as pain relievers because these drugs lengthen the clotting time of blood.
Immune thrombocytopenic purpura (ITP): MedlinePlus Medical Encyclopedia
Journal List Contemp Clin Dent v. On the 2 nd day after the patient reported, there was increased bleeding, hematoma and gingival enlargement in lower anterior region [ Figure 4 ], and on the 4 th day, hematoma formation was seen in lower anterior region lingually [ Figure 5 ].
Discussion There is marked variability in the clinical presentation of ITP. Puepura should be limited in duration unless demonstrated that symptomatic thrombocytopenia persists. In rare cases, ITP may become a long-term condition in adults and reappear, even after a symptom-free period.
Urea breath testing and stool antigen testing perform better than serology -based tests; moreover, serology may be false-positive after treatment with IVIG.
Keywords Idiopathic thrombocytopenic purpura; antiplatelet; antibodies; splenectomy; thrombopoietin.
The epidemiology of immune thrombocytopenic purpura.
Immune thrombocytopenic purpura – Wikipedia
Thrombopoietin TPO receptor agonists including eltrombopag and romiplostim have offered an important new option in treating ITP. Identifying drugs that cause acute thrombocytopenia: The spleen is the site of autoantibody production white pulp ; it is also the site of phagocytosis of autoantibody-coated platelets red pulp.
Sudden and severe loss of blood from the digestive tract may occur. This increased risk of death with ITP is largely concentrated in the middle-aged and elderly.
Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis. Foreign Allergic contact dermatitis Mantoux test. Sometimes the body may compensate by making abnormally large platelets.